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Highly Efficient Construction of Bisspirooxindoles Containing Vicinal Spirocenters through an Organocatalytic Modified Feist–Bénary Reaction
Author(s) -
Ahadi Somayeh,
Khavasi Hamid Reza,
Bazgir Ayoob
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301175
Subject(s) - vicinal , chemistry , catalysis , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry
We have developed an organocatalytic modified Feist–Bénary reaction of cyclic dicarbonyl compounds, isatins and cyclic α‐bromo dicarbonyl compounds. This method affords bisspirooxindole‐fused dihydrofurans containing two vicinal spiro centers. To the best of our knowledge, employing cyclic α‐halo dicarbonyl compounds for the synthesis of bisspirooxindole‐fused dihydrofurans has not been previously reported.