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Rhodium‐Catalyzed Synthesis of Amides from Aldehydes and Azides by Chelation‐Assisted CH Bond Activation
Author(s) -
Zhou Bing,
Yang Yaxi,
Shi Jingjing,
Feng Huijin,
Li Yuanchao
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301168
Subject(s) - chemistry , aldehyde , catalysis , rhodium , medicinal chemistry , aryl , chelation , alkyl , amine gas treating , intermolecular force , polymer chemistry , organic chemistry , molecule
CH activation : A Rh III ‐catalyzed direct aldehyde CH amidation has been achieved with sulfonyl, aryl, and alkyl azides as the amine sources, and release of N 2 as the only byproduct (see scheme). More importantly, this catalytic reaction proceeds in the absence of external oxidants or additives, under mild conditions, at neutral pH under air. This reaction represents a new avenue for practical intermolecular CN bond formation by aldehyde CH bond activation. Cp*=1,2,3,4,5‐Pentamethylcyclopentadiene