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Towards a General Synthesis of 3‐Metal‐Substituted β‐Lactams
Author(s) -
Baeza Beatriz,
Casarrubios Luis,
Sierra Miguel A.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201301114
Subject(s) - moiety , alkyne , cyclopentadienyl complex , aryl , chemistry , combinatorial chemistry , ring (chemistry) , stereochemistry , metal , computer science , database , organic chemistry , catalysis , alkyl
Joining metals and antibiotics : Studies towards a general method for the synthesis of β‐lactams that have a metal complex moiety attached to the C3‐position are reported (see scheme). The cis / trans selectivity of the reactions ranges from low in complexes containing the alkyne moiety joined directly to the cyclopentadienyl ring to complete when the metal moiety is separated from the reactive alkyne by an alkynyl–aryl fragment.