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TaMe 3 Cl 2 ‐Catalyzed Intermolecular Hydroaminoalkylation: A Simple Complex for Enhanced Reactivity and Expanded Substrate Scope
Author(s) -
Zhang Zhengxing,
Hamel JeanDenys,
Schafer Laurel L.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300992
Subject(s) - scope (computer science) , substrate (aquarium) , simple (philosophy) , reactivity (psychology) , catalysis , computer science , service (business) , chemistry , combinatorial chemistry , organic chemistry , programming language , business , oceanography , medicine , philosophy , alternative medicine , epistemology , pathology , geology , marketing
Tantalizingly simple : The common organometallic starting material TaMe 3 Cl 2 can be used for the catalytic CH functionalization reaction, hydroaminoalkylation. The substrate scope for this readily accessed compound includes unactivated terminal and internal alkenes, styrene derivatives, and both alkylaryl‐ and dialkyl secondary amines (see scheme).