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A Machine‐Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor‐1
Author(s) -
Battilocchio Claudio,
Deadman Benjamin J.,
Nikbin Nikzad,
Kitching Matthew O.,
Baxendale Ian R.,
Ley Steven V.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300696
Subject(s) - neurotensin , combinatorial chemistry , biochemical engineering , reagent , flow (mathematics) , process (computing) , computer science , receptor , biology , computational biology , process engineering , biological system , nanotechnology , chemistry , materials science , biochemistry , engineering , physics , organic chemistry , mechanics , programming language , neuropeptide
Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1 ), a neurotensin receptor‐1 antagonist, with its machine‐assisted flow chemistry alternative. By using these enabling tools, combined with solid‐supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist.