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Iridium(I) Hydroxides: Powerful Synthons for Bond Activation
Author(s) -
Truscott Byron J.,
Nelson David J.,
Lujan Cristina,
Slawin Alexandra M. Z.,
Nolan Steven P.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300669
Subject(s) - synthon , chemistry , iridium , carbene , steric effects , catalysis , reactivity (psychology) , crystal structure , molecule , medicinal chemistry , combinatorial chemistry , organic chemistry , medicine , alternative medicine , pathology
A family of iridium(I) hydroxides of the form [Ir(cod)(NHC)(OH)] (cod=1,5‐cyclooctadiene, NHC= N ‐heterocyclic carbene) is reported. Single‐crystal X‐ray analyses and computational methods were used to explore the structural characteristics and steric properties of these new complexes. The model complex [Ir(cod)(I i Pr)(OH)] (I i Pr=1,3‐(diisopropyl)imidazol‐2‐ylidene) undergoes reaction with a wide variety of substrates including boronic acids and silicon compounds. In addition, OH, NH and CH bond activation was achieved with alcohols, carboxylic acids, amines and various sp‐, sp 2 ‐ and sp 3 ‐hybridised carbon centres, giving access to a wide range of new Ir I complexes. These studies have allowed us to explore the exciting reactivity of this motif, revealing a versatile and useful synthon capable of activating important chemical bonds under mild (typically room temperature) conditions. No additives were required and, in the case of XH bond activation, water was the only waste product, rendering this an atom efficient procedure for bond activation. This system has great potential for the construction of new catalytic cycles for organic synthesis and small‐molecule activation.