A Gadolinium Complex Confined in Silica Nanoparticles as a Highly Efficient  T  1 / T  2  MRI Contrast Agent | Zendy

Wartenberg Nicolas | Zendy; Fries Pascal | Zendy; Raccurt Olivier | Zendy; Guillermo Armel | Zendy; Imbert Daniel | Zendy; Mazzanti Marinella | Zendy

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A Gadolinium Complex Confined in Silica Nanoparticles as a Highly Efficient T 1 / T 2 MRI Contrast Agent

Author(s) -

Wartenberg Nicolas,

Fries Pascal,

Raccurt Olivier,

Guillermo Armel,

Imbert Daniel,

Mazzanti Marinella

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201300635

Subject(s) - gadolinium , nanoparticle , contrast (vision) , chelation , biocompatible material , materials science , nanotechnology , chemical engineering , chemistry , biomedical engineering , optics , physics , medicine , engineering , metallurgy

Gd in silica : Noncovalent confinement of a monoaqua Gd chelate into biocompatible silica nanoparticles (NPs; see figure) by a sol‐gel method affords a new example of nanosized contrast agents with very high per‐Gd relaxivities. Such NPs provide a route to highly efficient multimodal contrast agents.

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