Premium
A Gadolinium Complex Confined in Silica Nanoparticles as a Highly Efficient T 1 / T 2 MRI Contrast Agent
Author(s) -
Wartenberg Nicolas,
Fries Pascal,
Raccurt Olivier,
Guillermo Armel,
Imbert Daniel,
Mazzanti Marinella
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300635
Subject(s) - gadolinium , nanoparticle , contrast (vision) , chelation , biocompatible material , materials science , nanotechnology , chemical engineering , chemistry , biomedical engineering , optics , physics , medicine , engineering , metallurgy
Gd in silica : Noncovalent confinement of a monoaqua Gd chelate into biocompatible silica nanoparticles (NPs; see figure) by a sol‐gel method affords a new example of nanosized contrast agents with very high per‐Gd relaxivities. Such NPs provide a route to highly efficient multimodal contrast agents.