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Development of a Metal‐Ion‐Mediated Base Pair for Electron Transfer in DNA
Author(s) -
Ehrenschwender Thomas,
Schmucker Wolfgang,
Wellner Christian,
Augenstein Timo,
Carl Patrick,
Harmer Jeffrey,
Breher Frank,
Wagenknecht HansAchim
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300593
Subject(s) - electron paramagnetic resonance , metal , dna , ion , chemistry , base pair , metal ions in aqueous solution , nucleobase , acceptor , electron transfer , fluorescence , ligand (biochemistry) , photochemistry , crystallography , nuclear magnetic resonance , biochemistry , organic chemistry , physics , receptor , quantum mechanics , condensed matter physics
A new C‐nucleoside structurally based on the hydroxyquinoline ligand was synthesized that is able to form stable pairs in DNA in both the absence and the presence of metal ions. The interactions between the metal centers in adjacent Cu II ‐mediated base pairs in DNA were probed by electron paramagnetic resonance (EPR) spectroscopy. The metal–metal distance falls into the range of previously reported values. Fluorescence studies with a donor–DNA–acceptor system indicate that photoinduced charge‐transfer processes across these metal‐ion‐mediated base pairs in DNA occur more efficiently than over natural base pairs.