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Enantio‐ and Regioselective Conjugate Addition of Organometallic Reagents to Linear Polyconjugated Nitroolefins
Author(s) -
Tissot Matthieu,
Alexakis Alexandre
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300538
Subject(s) - conjugate , regioselectivity , reagent , chemistry , copper , ligand (biochemistry) , addition reaction , combinatorial chemistry , organic chemistry , catalysis , mathematics , receptor , mathematical analysis , biochemistry
The copper‐catalysed conjugate addition of trialkylaluminium and dialkylzinc reagents to polyconjugated nitroolefins (nitrodiene and nitroenyne derivatives) is reported. A reversed Josiphos ligand L7 allows for the selective 1,4‐ or 1,6‐addition with high enantioselectivities.