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Asymmetric Mannich Reaction of α‐Keto Imines Catalyzed by Diarylprolinol Silyl Ether
Author(s) -
Hayashi Yujiro,
Sakamoto Daisuke,
Shomura Hiroki,
Hashizume Daisuke
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300513
Subject(s) - mannich reaction , silylation , trimethylsilyl , catalysis , silyl ether , chemistry , yield (engineering) , ether , organic chemistry , materials science , metallurgy
Synthetic methods : An asymmetric catalytic, desulfonylative Mannich reaction of α‐keto imines with aldehydes, as catalyzed by diarylprolinol silyl ether 1 , was developed. It gave the Mannich product in good yield with excellent anti and enantioselectivity (see scheme; Boc= tert ‐butoxycarbonyl, TMS=trimethylsilyl).