Dynamic Multivalency for Carbohydrate–Protein Recognition through Dynamic Combinatorial Libraries Based on Fe II –Bipyridine Complexes | Zendy

Reeh Philipp | Zendy; de Mendoza Javier | Zendy

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Dynamic Multivalency for Carbohydrate–Protein Recognition through Dynamic Combinatorial Libraries Based on Fe II –Bipyridine Complexes

Author(s) -

Reeh Philipp,

de Mendoza Javier

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201300464

Subject(s) - chemistry , concanavalin a , molecular recognition , carbohydrate , bipyridine , combinatorial chemistry , mannose , 2,2' bipyridine , biochemistry , molecule , crystallography , organic chemistry , crystal structure , in vitro

Molecular recognition : Dynamic combinatorial libraries (DCLs) exploiting multivalency effects and metal coordination have been employed for carbohydrate–protein recognition. The interaction of a three‐component DCL based on 2,2′‐bipyridine (bipy)–Fe II complexes with concanavalin A (ConA; see scheme) results in enhanced binding by multivalent presentation with a bias towards mannose‐containing library components.

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