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Construction of Long‐Wavelength Fluorescein Analogues and Their Application as Fluorescent Probes
Author(s) -
Xiong Xiaoqing,
Song Fengling,
Chen Gengwen,
Sun Wen,
Wang Jingyun,
Gao Pan,
Zhang Yukang,
Qiao Bo,
Li Wenfang,
Sun Shiguo,
Fan Jiangli,
Peng Xiaojun
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300418
Subject(s) - fluorescence , fluorescein , stain , computer science , quantum yield , in vivo , chemistry , biophysics , combinatorial chemistry , nanotechnology , materials science , optics , staining , biology , physics , medicine , microbiology and biotechnology , pathology
Born to dye : Five fluorescein analogues were synthesised (see scheme). One analogue was found to emit in the NIR region with a high quantum yield, excellent photostability and good permeability. Three derivatives were found to specifically stain mitochondria and one dye responds to thiols with a strong turn‐on NIR fluorescence signal and colorimetric change, in vitro and in vivo.