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New Cyclodextrin‐Bearing 8‐Hydroxyquinoline Ligands as Multifunctional Molecules
Author(s) -
Oliveri Valentina,
Puglisi Antonino,
Viale Maurizio,
Aiello Cinzia,
Sgarlata Carmelo,
Vecchio Graziella,
Clarke James,
Milton John,
Spencer John
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300237
Subject(s) - moiety , chemistry , cyclodextrin , 8 hydroxyquinoline , combinatorial chemistry , cytotoxicity , antioxidant , copper , superoxide dismutase , zinc , oxidative stress , aqueous solution , molecule , conjugate , stereochemistry , organic chemistry , in vitro , biochemistry , mathematical analysis , mathematics
Recent investigations have rekindled interest in 8‐hydroxyquinolines as therapeutic agents for cancer, Alzheimer’s disease, and other neurodegenerative disorders. Three new β‐cyclodextrin conjugates of 8‐hydroxyquinolines and their copper(II) and zinc(II) complexes have been synthesized and characterized spectroscopically. In addition to improving aqueous solubility, due to the presence of the cyclodextrin moiety, the hybrid systems have interesting characteristics including antioxidant activity, and their copper(II) complexes are efficient superoxide dismutase (SOD) mimics. The ligands and their copper(II) complexes show low cytotoxicity, attributed to the presence of the cyclodextrin moiety. These compounds have potential as therapeutic agents in diseases related both to metal dyshomeostasis and oxidative stress.