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3‐Isothiocyanato Oxindoles Serving as Powerful and Versatile Precursors to Structurally Diverse Dispirocyclic Thiopyrrolidineoxindoles through a Cascade Michael/Cyclization Process with Amino‐Thiocarbamate Catalysts
Author(s) -
Han WenYong,
Li ShiWu,
Wu ZhiJun,
Zhang XiaoMei,
Yuan WeiCheng
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300206
Subject(s) - thiocarbamate , stereocenter , catalysis , computer science , combinatorial chemistry , process (computing) , chemistry , organic chemistry , enantioselective synthesis , operating system
Cascading catalysis : 3‐Isothiocyanato oxindoles act as powerful and versatile precursors for a range of structurally diverse dispirocyclic thiopyrrolidineoxindoles containing two spiro‐quaternary and three contiguous stereogenic centers in quantitative yields with excellent disatereo‐ and enantioselectivities by only using 1 mol % amino‐thiocarbamate catalyst.