Catalytic Asymmetric Construction of Quaternary α‐Amino Acid Containing Pyrrolidines through 1,3‐Dipolar Cycloaddition of Azomethine Ylides to α‐Aminoacrylates | Zendy

Wang Zheng | Zendy; Luo Shuai | Zendy; Zhang Shoude | Zendy; Yang WuLin | Zendy; Liu YangZi | Zendy; Li Honglin | Zendy; Luo Xiaoyan | Zendy; Deng WeiPing | Zendy

Premium

Catalytic Asymmetric Construction of Quaternary α‐Amino Acid Containing Pyrrolidines through 1,3‐Dipolar Cycloaddition of Azomethine Ylides to α‐Aminoacrylates

Author(s) -

Wang Zheng,

Luo Shuai,

Zhang Shoude,

Yang WuLin,

Liu YangZi,

Li Honglin,

Luo Xiaoyan,

Deng WeiPing

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201300204

Subject(s) - cycloaddition , catalysis , chemistry , enantioselective synthesis , azomethine ylide , 1,3 dipolar cycloaddition , amino acid , combinatorial chemistry , stereochemistry , organic chemistry , medicinal chemistry , biochemistry

The first catalytic enantioselective 1,3‐dipolar cycloaddition of azomethine ylides to α‐aminoacrylate catalyzed by a AgOAc/ferrocenyl oxazolinylphosphine (FOXAP) system was developed, which exhibits excellent exo‐ and enantioselectivity (92–99 % ee ). This process provides efficient access to useful 4‐aminopyrrolidine‐2,4‐dicarboxylic acid (APDC)‐like compounds containing a unique quaternary α‐amino acid unit.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research