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Catalytic Version of Enediyne Cobalt‐Mediated Cycloaddition and Selective Access to Unusual Bicyclic Trienes
Author(s) -
Ventre Sandrine,
Simon Cédric,
Rekhroukh Feriel,
Malacria Max,
Amatore Muriel,
Aubert Corinne,
Petit Marc
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300134
Subject(s) - cycloaddition , bicyclic molecule , enediyne , cobalt , catalysis , substrate (aquarium) , chemistry , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , biology , ecology
Go cyclic! The use of [Co(H)(PMe 3 ) 4 ] as a cobalt catalyst allows the previously unattainable catalytic version of the cobalt‐mediated cycloaddition of enediynes without the requirement of thermal or light activation (see scheme). The importance of a chelating group on the substrate that can selectively direct the reaction pathway toward the classical polycyclic 1,3‐cyclohexadienes or a new family of bicyclic trienes is also demonstrated.