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Cascade Hydroamination/Redox Reaction for the Synthesis of Cyclic Aminals Catalyzed by a Combined Gold Complex and Brønsted Acid
Author(s) -
He YuPing,
Wu Hua,
Chen DianFeng,
Yu Jie,
Gong LiuZhu
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300052
Subject(s) - hydroamination , catalysis , relay , redox , combinatorial chemistry , computer science , chemistry , binary number , cascade , organic chemistry , mathematics , arithmetic , physics , power (physics) , chromatography , quantum mechanics
Relay catalysis : An unprecedented protocol for the synthesis of cyclic aminals has been realized under the relay catalysis of a gold(I)/Brønsted acid binary system to generate cyclic aminals in excellent yields of up to 99 % with moderate to high diastereoselectivity (see scheme; up to 95:5 d.r.).