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Selective, Sensitive, and Rapid Analysis with Lateral‐Flow Assays Based on Antibody‐Gated Dye‐Delivery Systems: The Example of Triacetone Triperoxide
Author(s) -
Climent Estela,
Gröninger Delia,
Hecht Mandy,
Walter M. Astrid,
MartínezMáñez Ramón,
Weller Michael G.,
Sancenón Félix,
Amorós Pedro,
Rurack Knut
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201300031
Subject(s) - analyte , chemistry , fluorescence , chromatography , combinatorial chemistry , analytical chemistry (journal) , quantum mechanics , physics
Set them free : Brightly fluorescent indicators that are loaded into mesoporous silica nanoparticle carriers, capped with bulky antibodies, are released into the lateral flow of a test strip upon analyte arrival. Integration of the system into a rapid, simple flow test with fluorescence readout is applied for the selective and sensitive determination of the presence of triacetone triperoxide (TATP) as a prototype small‐molecule analyte (see figure).