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Cover Picture: Catalytic Enantioselective Desymmetrisation as a Tool for the Synthesis of Hodgkinsine and Hodgkinsine B (Chem. Eur. J. 52/2012)
Author(s) -
Snell Robert H.,
Durbin Matthew J.,
Woodward Robert L.,
Willis Michael C.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201290220
Subject(s) - chemistry , enantioselective synthesis , catalysis , alloy , crystallography , organic chemistry
An enantioselective Pd‐catalyzed allylation processes has been used to achieve the highly selective desymmetrization of meso ‐chimonanthine. The desymmetrized material is carried through five subsequent transformations to deliver the alkaloid natural product hodgkinsine B. The naturally occurring alkaloid was originally isolated from the species Hodgkinsonia frutescens (shown as the background image) from the family Rubiaceae. For more details see the Full Paper by M. C. Willis et al. on page 16754 ff . Background image used with permission from Blackdiamond Images.