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Inside Cover: De Novo Design, Synthesis and Characterisation of MP3, A New Catalytic Four‐Helix Bundle Hemeprotein (Chem. Eur. J. 50/2012)
Author(s) -
Faiella Marina,
Maglio Ornella,
Nastri Flavia,
Lombardi Angela,
Lista Liliana,
Hagen Wilfred R.,
Pavone Vincenzo
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201290213
Subject(s) - cover (algebra) , protein design , chemistry , computational biology , computer science , biochemistry , biology , protein structure , engineering , mechanical engineering
Scientists are similar to artists. Entering a museum, painters and sculptors can take inspiration for their work. Similarly, chemists can look to the natural portfolio of proteins and create something completely new by discovering the minimal structural elements required for a functional enzyme. Amino acids and prosthetic groups are the chemists colors and pencils, while de novo design principles and computational tools have the same value as perspective and rules of proportion, without which elements could not be arranged into a harmonious whole. In their Full Paper on page 15960 ff. , M. Faiella et al. borrow the structural elements of ferritins and the functional residues of peroxidases for the de novo design of a minimally sized, peptide‐based catalyst.