Premium
Cover Picture: A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target (Chem. Eur. J. 50/2012)
Author(s) -
Faller Peter,
Hureau Christelle
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201290212
Subject(s) - phthalocyanine , crystallography , dimer , supramolecular chemistry , chemistry , materials science , photochemistry , nanotechnology , crystal structure , organic chemistry
The main players concerning the role of metal ions in the neurodegenerative Alzheimer's disease (AD) are shown in this cover picture: The d orbital stands for the importance of the first‐row transition metals (mainly Cu and Fe), and the unpaired electron for the redox reactivity and the production of harmful reactive radicals. The bottom two pictures show the amyloids that contain Cu, Zn, and Fe (right) and the Cu/Fe‐catalyzed production of reactive oxygen species (left), both occurring in AD. The upper part shows two therapeutic approaches for treatment of AD based on selective intervention in the metal metabolism. For more information, see the Concept article by P. Faller and C. Hureau on page 15910 ff.