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Inside Cover: Synthesis of Deoxynucleoside Triphosphates that Include Proline, Urea, or Sulfonamide Groups and Their Polymerase Incorporation into DNA (Chem. Eur. J. 42/2012)
Author(s) -
Hollenstein Marcel
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201290183
Subject(s) - nucleoside , primer (cosmetics) , chemistry , dna polymerase , polymerase , biochemistry , dna , combinatorial chemistry , organic chemistry
Five base‐modified nucleoside triphosphates (dNTPs) adorned with functionalities that play a central role in organocatalysis (i.e., proline, urea and sulfamide groups) were synthesized. In addition, these dNTPs were shown to be compatible with methods of in vitro selection since they are good substrates for polymerases, both in primer extension reactions and the polymerase chain reaction (PCR). Thus these modified dNTPs could supplement the chemical collection of DNA enzymes when used in selection experiments. For more information, see the Full Paper by M. Hollenstein on page 13320 ff.