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Inside Cover: A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins (Chem. Eur. J. 31/2012)
Author(s) -
Chae Pil Seok,
Rasmussen Søren G. F.,
Rana Rohini R.,
Gotfryd Kamil,
Kruse Andrew C.,
Manglik Aashish,
Cho Kyung Ho,
Nurva Shailika,
Gether Ulrik,
Guan Lan,
Loland Claus J.,
Byrne Bernadette,
Kobilka Brian K.,
Gellman Samuel H.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201290131
Subject(s) - amphiphile , solubilization , membrane , chemistry , membrane protein , cover (algebra) , copolymer , biochemistry , organic chemistry , engineering , polymer , mechanical engineering
A class of structurally new amphiphile based on steroidal lipophilic groups have been prepared by P. S. Chae et al. on page 9485 ff. The results show that the new amphiphiles confer enhanced stability to a variety of membrane proteins in solution relative to popular conventional detergent dodecylmaltoside (DDM). The potential of the new amphiphiles as tools for solubilization, isolation, and stabilization is evident from their success with a variety of membrane proteins.