Premium
Cover Picture: An Efficient Mixed‐Ligand Pd Catalytic System to Promote CN Coupling for the Synthesis of N ‐Arylaminotriazole Nucleosides (Chem. Eur. J. 8/2012)
Author(s) -
Fan Yuting,
Xia Yi,
Tang Jingjie,
Ziarelli Fabio,
Qu Fanqi,
Rocchi Palma,
Iovanna Juan L.,
Peng Ling
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201290025
Subject(s) - xantphos , catalysis , ligand (biochemistry) , chemistry , substrate (aquarium) , combinatorial chemistry , oxidative coupling of methane , stereochemistry , coupling (piping) , medicinal chemistry , organic chemistry , palladium , materials science , receptor , biology , biochemistry , ecology , metallurgy
A mixed‐ligand system of Pd/Synphos/Xantphos promotes effective CN coupling in the synthesis of various N ‐arylaminotriazole and N ‐arylaminopurine nucleoside analogues. This catalytic system is strikingly powerful and efficient, allowing for unparalleled substrate scope and high product yields as well as promotion of CCl bond activation for CN coupling. 31 P NMR investigations provided useful evidence favoring a mechanism in which the catalytic reactions are mediated by ligand exchange during both Pd catalyst formation and oxidative insertion. For more details see the Communication by L. Peng et al. on page 2221 ff.