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Cover Picture: Dinucleosides with Non‐Natural Backbones: A New Class of Ribonuclease A and Angiogenin Inhibitors (Chem. Eur. J. 6/2012)
Author(s) -
Debnath Joy,
Dasgupta Swagata,
Pathak Tanmaya
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201290017
Subject(s) - angiogenin , cover (algebra) , character (mathematics) , chemistry , class (philosophy) , natural (archaeology) , stereochemistry , combinatorial chemistry , biochemistry , computer science , biology , artificial intelligence , mathematics , engineering , genetics , mechanical engineering , geometry , angiogenesis , paleontology
The introduction of a non‐natural backbone into a dinucleoside has proven to be a good venture for the design of inhibitors with lower ionic character. The presence of the non‐natural backbone with one carboxylic group was effective in increasing the inhibitory activity of the protein compared with the phosphate analogue. It is possible that this kind of modification can be utilized for the identification of potent inhibitors of ribonucleases. For more details see the Full Paper by T. Pathak, S. Dasgupta, and J. Debnath on page 1618 ff.