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Cyclic iso DGR Peptidomimetics as Low‐Nanomolar α v β 3 Integrin Ligands
Author(s) -
Mingozzi Michele,
Dal Corso Alberto,
Marchini Mattia,
Guzzetti Ileana,
Civera Monica,
Piarulli Umberto,
Arosio Daniela,
Belvisi Laura,
Potenza Donatella,
Pignataro Luca,
Gennari Cesare
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204639
Subject(s) - integrin , peptidomimetic , representation (politics) , computer science , chemistry , ligand (biochemistry) , computational biology , stereochemistry , crystallography , computer graphics (images) , nanotechnology , receptor , biochemistry , materials science , biology , peptide , politics , political science , law
A perfect fit : Shown here is the docking best pose of a low‐nanomolar α v β 3 integrin ligand cyclo [DKP‐ iso DGR] (atom color tube representation; see figure) into the receptor binding pocket, overlaid on the bound conformation of Cilengitide (green tube representation). The extended iso DGR conformation permits all the important interactions with the extracellular domain of the α v β 3 integrin. The metal ion in the MIDAS region is represented by a magenta sphere.