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Selective Ruthenium‐Catalyzed Transfer Hydrogenations of Nitriles to Amines with 2‐Butanol
Author(s) -
Werkmeister Svenja,
Bornschein Christoph,
Junge Kathrin,
Beller Matthias
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204633
Subject(s) - ruthenium , catalysis , transfer hydrogenation , chemistry , reagent , butane , homogeneous , butanol , organic chemistry , hydrogen , n butanol , primary (astronomy) , 2 butanol , combinatorial chemistry , ethanol , physics , astronomy , thermodynamics
Transfer your hydrogen : Fast and general transfer hydrogenation of nitriles to form primary amines is possible with a homogeneous Ru/1,4‐bis(diphenylphosphino)butane (DPPB) catalyst (see scheme). The use of 2‐butanol as the hydrogen‐transfer reagent is essential for the selective reduction of aromatic, heteroaromatic, and aliphatic nitriles with this system.