Direct Synthesis of Diverse β‐Fluoroethylamines by a Multicomponent Protocol | Zendy

Prakash G. K. Surya | Zendy; Gurung Laxman | Zendy; Jog Parag V. | Zendy; Tanaka Shinji | Zendy; Thomas Tisa Elizabeth | Zendy; Ganesh Nimisha | Zendy; Haiges Ralf | Zendy; Mathew Thomas | Zendy; Olah George A. | Zendy

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Direct Synthesis of Diverse β‐Fluoroethylamines by a Multicomponent Protocol

Author(s) -

Prakash G. K. Surya,

Gurung Laxman,

Jog Parag V.,

Tanaka Shinji,

Thomas Tisa Elizabeth,

Ganesh Nimisha,

Haiges Ralf,

Mathew Thomas,

Olah George A.

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201204621

Subject(s) - protocol (science) , ethylamine , methane , computer science , combinatorial chemistry , chemistry , database , organic chemistry , medicine , alternative medicine , pathology

No imines! A direct multicomponent protocol for the synthesis of highly diverse derivatives of β‐fluoro(phenylsulfonyl)ethylamine has been developed (see scheme) by use of a Mannich‐type reaction from their molecular subunits, α‐fluoro‐α‐nitro(phenylsulfonyl)methane ( 1 a ) or α‐fluorobis(phenylsulfonyl)methane ( 1 b ), formalin, and various primary and secondary amines. The products are obtained in high yields and selectivity even, in many cases, without the use of base.

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