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Direct Synthesis of Diverse β‐Fluoroethylamines by a Multicomponent Protocol
Author(s) -
Prakash G. K. Surya,
Gurung Laxman,
Jog Parag V.,
Tanaka Shinji,
Thomas Tisa Elizabeth,
Ganesh Nimisha,
Haiges Ralf,
Mathew Thomas,
Olah George A.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204621
Subject(s) - protocol (science) , ethylamine , methane , computer science , combinatorial chemistry , chemistry , database , organic chemistry , medicine , alternative medicine , pathology
No imines! A direct multicomponent protocol for the synthesis of highly diverse derivatives of β‐fluoro(phenylsulfonyl)ethylamine has been developed (see scheme) by use of a Mannich‐type reaction from their molecular subunits, α‐fluoro‐α‐nitro(phenylsulfonyl)methane ( 1 a ) or α‐fluorobis(phenylsulfonyl)methane ( 1 b ), formalin, and various primary and secondary amines. The products are obtained in high yields and selectivity even, in many cases, without the use of base.