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A Cooperative Hydrogen‐Bond‐Promoted Organophotoredox Catalysis Strategy for Highly Diastereoselective, Reductive Enone Cyclization
Author(s) -
Neumann Matthias,
Zeitler Kirsten
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204573
Subject(s) - thiourea , enone , organocatalysis , computer science , chemistry , combinatorial chemistry , catalysis , photoredox catalysis , organic chemistry , photocatalysis , enantioselective synthesis
Metal‐free cooperation : The cooperative combination of Eosin Y as a photoredox catalyst with organocatalytic thiourea allows for the highly diastereoselective construction of trans ‐1,2‐cycloalkanes and heterocycles. This new efficient, cooperative organophotoredox/organocatalysis protocol presents a valuable alternative to metal‐based photoredox approaches and is the first example of combining photoredox with hydrogen‐bond catalysis (see scheme).