Total Synthesis of an Immunomodulatory Phosphoglycolipid from Thermophilic Bacteria | Zendy

Lin HongJyune | Zendy; Adak Avijit Kumar | Zendy; Reddy L. Vijaya Raghava | Zendy; Wu ShihHsiung | Zendy; Lin ChunCheng | Zendy

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Total Synthesis of an Immunomodulatory Phosphoglycolipid from Thermophilic Bacteria

Author(s) -

Lin HongJyune,

Adak Avijit Kumar,

Reddy L. Vijaya Raghava,

Wu ShihHsiung,

Lin ChunCheng

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201204550

Subject(s) - thermophile , bacteria , glycosylation , acceptor , chemistry , total synthesis , microbiology and biotechnology , combinatorial chemistry , stereochemistry , biochemistry , biology , genetics , physics , condensed matter physics

A method for the stereocontrolled synthesis of a bacterial phosphoglycolipid (PGL 1 ) isolated from thermophilic bacteria is described. The key features of the synthesis include a highly α‐selective glycosylation reaction between a trichloroacetimidate donor and a D ‐lyxose‐derived primary alcohol acceptor and the late‐stage incorporation of the phospholipid.

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