Premium
Highly Diastereo‐ and Enantioselective Cross‐Cascade Reactions of Different Enones
Author(s) -
Huang Huicai,
Wu Wenbin,
Zhu Kailong,
Hu Juan,
Ye Jinxing
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204520
Subject(s) - stereocenter , cascade , enantioselective synthesis , computer science , amine gas treating , scheme (mathematics) , combinatorial chemistry , chemistry , organic chemistry , catalysis , mathematics , chromatography , mathematical analysis
Cascading ketones! The first highly efficient asymmetric cross‐cascade reaction of different α,β‐unsaturated ketones catalyzed by an easily prepared bulky primary amine salt has been developed. It affords the corresponding diverse products containing three to four contiguous stereocenters with excellent enantio‐ and diastereoselectivities (see scheme).