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Mild Copper‐Mediated Direct Oxidative Cross‐Coupling of 1,3,4‐Oxadiazoles with Polyfluoroarenes by Using Dioxygen as Oxidant
Author(s) -
Zou LiangHua,
Mottweiler Jakob,
Priebbenow Daniel L.,
Wang Jun,
Stubenrauch Jan Alexander,
Bolm Carsten
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204502
Subject(s) - acetonitrile , copper , aryl , oxidative phosphorylation , chemistry , oxidative coupling of methane , combinatorial chemistry , oxygen , coupling (piping) , photochemistry , organic chemistry , materials science , catalysis , metallurgy , biochemistry , alkyl
CH 3 CN and O 2 do the trick! A copper‐mediated direct oxidative cross‐coupling of 2‐(het)aryl‐1,3,4‐oxadiazoles with polyhaloarenes under mild reaction conditions has been developed (see scheme). The process provides a concise access to biaryl structures containing polyhaloarenes, which are of interest in the fields of pharmaceuticals and functional materials. Acetonitrile and oxygen play crucial roles.