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Rhodium(III)‐Catalyzed Amidation of Aryl Ketone O ‐Methyl Oximes with Isocyanates by CH Activation: Convergent Synthesis of 3‐Methyleneisoindolin‐1‐ones
Author(s) -
Zhou Bing,
Hou Wei,
Yang Yaxi,
Li Yuanchao
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204448
Subject(s) - rhodium , regioselectivity , ketone , aryl , catalysis , chemistry , methyl ketone , substrate (aquarium) , annulation , oxime , organic chemistry , functional group , medicinal chemistry , alkyl , oceanography , polymer , geology
Going green! The rhodium(III)‐catalyzed annulation of aryl ketone O ‐methyl oximes with isocyanates for the synthesis of 3‐methyleneisoindolin‐1‐ones is reported (see scheme). This reaction exhibits high regioselectivity, functional‐group tolerance, and broad substrate scope, without the use of additives or production of environmentally hazardous waste.