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[(η 6 ‐Praziquantel)Cr(CO) 3 ] Derivatives with Remarkable In Vitro Anti‐schistosomal Activity
Author(s) -
Patra Malay,
Ingram Katrin,
Pierroz Vanessa,
Ferrari Stefano,
Spingler Bernhard,
Gasser Robin B.,
Keiser Jennifer,
Gasser Gilles
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204291
Subject(s) - praziquantel , schistosoma mansoni , in vitro , chemistry , stereochemistry , cytotoxic t cell , nuclear chemistry , schistosomiasis , pharmacology , biology , helminths , immunology , biochemistry
The antischistosomal effect of two [(η 6 ‐praziquantel)Cr(CO) 3 ] derivatives was investigated. The compounds (see figure: Cr purple, N blue, O red) were prepared in a one‐step procedure from commercially available praziquantel. Both derivatives show a high in vitro activity against Schistosoma mansoni , a parasitic trematode, and only a minor cytotoxic effect on selected mammalian cell lines.
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