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Cooperative Iron–Brønsted Acid Catalysis: Enantioselective Hydrogenation of Quinoxalines and 2 H ‐1,4‐Benzoxazines
Author(s) -
Fleischer Steffen,
Zhou Shaolin,
Werkmeister Svenja,
Junge Kathrin,
Beller Matthias
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204236
Subject(s) - enantioselective synthesis , catalysis , brønsted–lowry acid–base theory , chemistry , asymmetric hydrogenation , organic chemistry , metal , hydrogen , combinatorial chemistry
Come together! A selective Fe‐catalysed enantioselective reduction of quinoxalines and benzoxazines with hydrogen is demonstrated. Key to success is the combination of a chiral Brønsted acid and a well‐defined non‐chiral Fe hydrogenation catalyst. This methodology constitutes an attractive and environmentally favourable alternative to well‐established asymmetric hydrogenations by using precious‐metal‐based catalysts.