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Palladium‐Catalyzed Intermolecular Desulfinylative Cross‐Coupling of Heteroaromatic Sulfinates
Author(s) -
Sévigny Stéphane,
Forgione Pat
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204201
Subject(s) - palladium , catalysis , intermolecular force , coupling (piping) , computer science , nucleophile , chemistry , broad spectrum , microwave irradiation , coupling reaction , combinatorial chemistry , organic chemistry , nanotechnology , materials science , molecule , metallurgy
Beauty lies in simplicity : An efficient and environmentally benign palladium‐catalyzed protocol has been developed using a sulfinate as a nucleophilic coupling partner. The sulfinate position is arylated chemoselectively in very good yields. The bench‐stable, non‐hygroscopic heteroaromatic sulfinate salts rapidly undergo cross‐coupling without the need of a co‐catalyst, base, or additives (see scheme; mw=microwave).
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