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Copper‐Catalyzed Aerobic Oxidative CH and CC Functionalization of 1‐[2‐(Arylamino)aryl]ethanones Leading to Acridone Derivatives
Author(s) -
Yu Jipan,
Yang Haijun,
Jiang Yuyang,
Fu Hua
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204169
Subject(s) - acridone , catalysis , chemistry , intramolecular force , surface modification , aryl , pyridine , combinatorial chemistry , oxidative phosphorylation , oxygen , medicinal chemistry , organic chemistry , alkyl , biochemistry
Abstract Efficient copper‐catalyzed aerobic oxidative CH and CC functionalization of 1‐[2‐(arylamino)aryl]ethanones leading to acridones has been developed. The procedure involves cleavage of aromatic CH and acetyl CC bonds with intramolecular formation of a diarylketone bond. The protocol uses inexpensive Cu(O 2 CCF 3 ) 2 as catalyst, pyridine as additive, and economical and environmentally friendly oxygen as the oxidant, and the corresponding acridones with various functional groups were obtained in moderate to good yields.