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Glycosylated Nanoscale Surfaces: Preparation and Applications in Medicine and Molecular Biology
Author(s) -
Kennedy David C.,
Grünstein Dan,
Lai ChianHui,
Seeberger Peter H.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204155
Subject(s) - biomolecule , nanotechnology , glycobiology , nanoscopic scale , cell adhesion , extracellular , adhesion , chemistry , nanomaterials , cell , computational biology , microbiology and biotechnology , glycan , biophysics , biochemistry , biology , materials science , glycoprotein , organic chemistry
Carbohydrates on cell surfaces are critical components of the extracellular landscape and contribute to cell signalling, motility, adhesion and recognition. Multivalent effects are essential to these interactions that are inherently weak. Carbohydrate‐functionalised surfaces meet an important need for studying the multivalent interactions between carbohydrates and other biomolecules. Innovations in nanomaterials are revolutionising how these carbohydrate interfaces are studied and underscore their importance in the cosmos of biochemical interactions.