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Solid‐Phase Methodology for Synthesis of O ‐Alkylated Aromatic Oligoamide Inhibitors of α‐Helix‐Mediated Protein–Protein Interactions
Author(s) -
Murphy Natasha S.,
Prabhakaran Panchami,
Azzarito Valeria,
Plante Jeffrey P.,
Hardie Michaele J.,
Kilner Colin A.,
Warriner Stuart L.,
Wilson Andrew J.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201204098
Subject(s) - helix (gastropod) , context (archaeology) , chemistry , alkylation , peptidomimetic , combinatorial chemistry , side chain , stereochemistry , biochemistry , peptide , organic chemistry , biology , ecology , snail , catalysis , paleontology , polymer
Rapid access to rigid rods : A method is described for the synthesis of 3‐ O ‐alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α‐helix mimetic inhibitors of protein–protein interactions (see scheme; Fmoc=9‐fluorenylmethoxycarbonyl).