Solid‐Phase Methodology for Synthesis of  O ‐Alkylated Aromatic Oligoamide Inhibitors of α‐Helix‐Mediated Protein–Protein Interactions | Zendy

Murphy Natasha S. | Zendy; Prabhakaran Panchami | Zendy; Azzarito Valeria | Zendy; Plante Jeffrey P. | Zendy; Hardie Michaele J. | Zendy; Kilner Colin A. | Zendy; Warriner Stuart L. | Zendy; Wilson Andrew J. | Zendy

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Solid‐Phase Methodology for Synthesis of O ‐Alkylated Aromatic Oligoamide Inhibitors of α‐Helix‐Mediated Protein–Protein Interactions

Author(s) -

Murphy Natasha S.,

Prabhakaran Panchami,

Azzarito Valeria,

Plante Jeffrey P.,

Hardie Michaele J.,

Kilner Colin A.,

Warriner Stuart L.,

Wilson Andrew J.

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201204098

Subject(s) - helix (gastropod) , context (archaeology) , chemistry , alkylation , peptidomimetic , combinatorial chemistry , side chain , stereochemistry , biochemistry , peptide , organic chemistry , biology , ecology , snail , catalysis , paleontology , polymer

Rapid access to rigid rods : A method is described for the synthesis of 3‐ O ‐alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α‐helix mimetic inhibitors of protein–protein interactions (see scheme; Fmoc=9‐fluorenylmethoxycarbonyl).

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