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Brønsted Acid/Rhodium(II) Cooperative Catalytic Asymmetric Three‐Component Aldol‐Type Reaction for the Synthesis of 3‐Amino Oxindoles
Author(s) -
Ren Lei,
Lian XiaoLei,
Gong LiuZhu
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203993
Subject(s) - aldol reaction , diazo , rhodium , enantioselective synthesis , stereoselectivity , catalysis , brønsted–lowry acid–base theory , chemistry , component (thermodynamics) , stereochemistry , combinatorial chemistry , organic chemistry , physics , thermodynamics
Cooperation is key! Chiral Brønsted acid/rhodium(II) cooperative catalysis enabled an enantioselective three‐component aldol‐type reaction of 3‐diazo oxindoles and anilines with glyoxylates to give highly functionalized and structurally diverse 3‐amino oxindoles in high stereoselectivity (>20:1 d.r., 99 % ee ; see scheme).