Brønsted Acid/Rhodium(II) Cooperative Catalytic Asymmetric Three‐Component Aldol‐Type Reaction for the Synthesis of 3‐Amino Oxindoles | Zendy

Ren Lei | Zendy; Lian XiaoLei | Zendy; Gong LiuZhu | Zendy

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Brønsted Acid/Rhodium(II) Cooperative Catalytic Asymmetric Three‐Component Aldol‐Type Reaction for the Synthesis of 3‐Amino Oxindoles

Author(s) -

Ren Lei,

Lian XiaoLei,

Gong LiuZhu

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201203993

Subject(s) - aldol reaction , diazo , rhodium , enantioselective synthesis , stereoselectivity , catalysis , brønsted–lowry acid–base theory , chemistry , component (thermodynamics) , stereochemistry , combinatorial chemistry , organic chemistry , physics , thermodynamics

Cooperation is key! Chiral Brønsted acid/rhodium(II) cooperative catalysis enabled an enantioselective three‐component aldol‐type reaction of 3‐diazo oxindoles and anilines with glyoxylates to give highly functionalized and structurally diverse 3‐amino oxindoles in high stereoselectivity (>20:1 d.r., 99 % ee ; see scheme).

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