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Multifunctional Core‐Shell‐Corona‐Type Polymeric Micelles for Anticancer Drug‐Delivery and Imaging
Author(s) -
Bastakoti Bishnu Prasad,
Wu Kevin C.W.,
Inoue Masamichi,
Yusa Shinichi,
Nakashima Kenichi,
Yamauchi Yusuke
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203958
Subject(s) - micelle , drug delivery , aqueous solution , chemistry , corona (planetary geology) , chemical engineering , nanotechnology , drug carrier , drug , materials science , organic chemistry , physics , astrobiology , venus , engineering , psychology , psychiatry
We have developed core‐shell‐corona‐type polymeric micelles that can integrate multiple functions in one system, including the capability of accommodating hydrophobic dyes into core and hydrophilic drug into the shell, as well as pH‐triggered drug‐release. The neutral and hydrophilic corona sterically stabilizes the multifunctional polymeric micelles in aqueous solution. The mineralization of calcium phosphate (CaP) on the PAA domain not only enhances the diagnostic efficacy of organic dyes, but also works as a diffusion barrier for the controlled release.