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Bioluminescent Microcapsules: Applications in Activating a Photosensitizer
Author(s) -
Zhao Jie,
Fei Jinbo,
Gao Liang,
Cui Wei,
Yang Yang,
Wang Anhe,
Li Junbai
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203922
Subject(s) - photosensitizer , bioluminescence , covalent bond , chemistry , luciferin , luciferase , photodynamic therapy , rose bengal , nanotechnology , layer (electronics) , biophysics , materials science , photochemistry , biochemistry , biology , organic chemistry , transfection , gene
Bioluminescent microcapsules uploading D ‐luciferin have been fabricated by using the covalent assembly of firefly luciferase and alginate dialdehyde through a layer‐by‐layer technique. Such assembled microcapsules can produce visible light in the region of 520–680 nm, which can activate the photosensitizers rose bengal (RB) and hypocrellin B (HB) after adding ATP. The microcapsules uploading photosensitizers (RB or HB) have an obvious property to prevent the proliferation of tumor cells in the dark. The assembled bioluminescent microcapsules can be potentially used as photon donors for bioimaging, ATP detection, and photodynamic therapy.