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An Efficient Method for Sterically Demanding Suzuki–Miyaura Coupling Reactions
Author(s) -
Zhao Qing,
Li Chengxi,
Senanayake Chris H.,
Tang Wenjun
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203898
Subject(s) - steric effects , catalysis , ligand (biochemistry) , chemistry , isopropyl , combinatorial chemistry , computer science , coupling reaction , database , organic chemistry , biochemistry , receptor
An efficient method for sterically demanding Suzuki–Miyaura coupling reactions has been developed with two catalysts, Pd/BI‐DIME (see scheme) and Pd/phenanthrene‐based ligand. The Pd/BI‐DIME catalyst facilitates the syntheses of extremely hindered biaryls bearing ortho ‐isopropyl substituents. The other catalyst is efficient for the synthesis of functionalized tetra‐ ortho ‐substituted biaryls at low catalyst loadings.