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Iron‐Catalyzed Oxidative Amidation of Tertiary Amines with Aldehydes
Author(s) -
Li Yuanming,
Jia Fan,
Li Zhiping
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203824
Subject(s) - iminium , chemistry , oxidative phosphorylation , catalysis , amide , peroxide , oxidative coupling of methane , combinatorial chemistry , tertiary amine , organic chemistry , primary (astronomy) , hydrogen peroxide , biochemistry , physics , astronomy
Unconventional couple : A new oxidative coupling protocol for amide bond formation has been developed (see scheme). The method provides an efficient and practical route for the synthesis of tertiary amides from readily available tertiary amines and aldehydes in the presence of a simple FeCl 2 catalyst. Mechanistic studies indicated that a peroxide and an iminium ion act as the reactive intermediates in this oxidative amidation.