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Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour‐Associated Galectins
Author(s) -
Bartoloni Marco,
Domínguez Blanca E.,
Dragoni Elisa,
Richichi Barbara,
Fragai Marco,
André Sabine,
Gabius HansJoachim,
Ardá Ana,
Luchinat Claudio,
JiménezBarbero Jesús,
Nativi Cristina
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203794
Subject(s) - matrix metalloproteinase , galectin , bifunctional , lectin , conjugate , chemistry , cancer research , biochemistry , biology , mathematics , mathematical analysis , catalysis
A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal‐3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time.