Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour‐Associated Galectins | Zendy

Bartoloni Marco | Zendy; Domínguez Blanca E. | Zendy; Dragoni Elisa | Zendy; Richichi Barbara | Zendy; Fragai Marco | Zendy; André Sabine | Zendy; Gabius HansJoachim | Zendy; Ardá Ana | Zendy; Luchinat Claudio | Zendy; JiménezBarbero Jesús | Zendy; Nativi Cristina | Zendy

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Targeting Matrix Metalloproteinases: Design of a Bifunctional Inhibitor for Presentation by Tumour‐Associated Galectins

Author(s) -

Bartoloni Marco,

Domínguez Blanca E.,

Dragoni Elisa,

Richichi Barbara,

Fragai Marco,

André Sabine,

Gabius HansJoachim,

Ardá Ana,

Luchinat Claudio,

JiménezBarbero Jesús,

Nativi Cristina

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201203794

Subject(s) - matrix metalloproteinase , galectin , bifunctional , lectin , conjugate , chemistry , cancer research , biochemistry , biology , mathematics , mathematical analysis , catalysis

A new strategy to exploit galectin presence to target matrix metalloproteinases (MMPs) is presented. A bifunctional conjugate with lactose and an inhibitor for MMPs is able to bind MMP and Gal‐3 simultaneously. This compound might allow the lectin to attract the MMP inhibitor to the tumour site and to block protumoural activities of the lectin at the same time.

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