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Catalytic Enantioselective Decarboxylative Cyanoalkylation of Imines by Using Palladium Pincer Complexes with C 2 ‐Symmetric Chiral Bis(imidazoline)s
Author(s) -
Hyodo Kengo,
Kondo Masaru,
Funahashi Yasuhiro,
Nakamura Shuichi
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203782
Subject(s) - enantioselective synthesis , chemistry , catalysis , yield (engineering) , pincer movement , palladium , organic chemistry , benzene , combinatorial chemistry , medicinal chemistry , materials science , metallurgy
Manifold products : The enantioselective decarboxylative Mannich‐type reaction of cyanoacetic acid with N ‐ (2‐pyridinesulfonyl)imines catalyzed by chiral 1,3‐bis(imidazolin‐2‐yl)benzene (Phebim)–Pd II complexes afforded products with good enantioselectivity (see scheme). The reaction was applied to a wide range of imines with good yield and enantioselectivity. The obtained products can be converted into various compounds without the loss of enantiopurity.