Catalytic Enantioselective Decarboxylative Cyanoalkylation of Imines by Using Palladium Pincer Complexes with  C  2 ‐Symmetric Chiral Bis(imidazoline)s | Zendy

Hyodo Kengo | Zendy; Kondo Masaru | Zendy; Funahashi Yasuhiro | Zendy; Nakamura Shuichi | Zendy

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Catalytic Enantioselective Decarboxylative Cyanoalkylation of Imines by Using Palladium Pincer Complexes with C 2 ‐Symmetric Chiral Bis(imidazoline)s

Author(s) -

Hyodo Kengo,

Kondo Masaru,

Funahashi Yasuhiro,

Nakamura Shuichi

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201203782

Subject(s) - enantioselective synthesis , chemistry , catalysis , yield (engineering) , pincer movement , palladium , organic chemistry , benzene , combinatorial chemistry , medicinal chemistry , materials science , metallurgy

Manifold products : The enantioselective decarboxylative Mannich‐type reaction of cyanoacetic acid with N ‐ (2‐pyridinesulfonyl)imines catalyzed by chiral 1,3‐bis(imidazolin‐2‐yl)benzene (Phebim)–Pd II complexes afforded products with good enantioselectivity (see scheme). The reaction was applied to a wide range of imines with good yield and enantioselectivity. The obtained products can be converted into various compounds without the loss of enantiopurity.

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