Synthesis, Characterisation and In Vitro Anticancer Activity of Hexanuclear Thiolato‐Bridged Arene Ruthenium Metalla‐Prisms | Zendy

Furrer Mona A. | Zendy; Garci Amine | Zendy; DenoyelleDiMuro Emmanuel | Zendy; Trouillas Patrick | Zendy; Giannini Federico | Zendy; Furrer Julien | Zendy; Clavel Catherine M. | Zendy; Dyson Paul J. | Zendy; SüssFink Georg | Zendy; Therrien Bruno | Zendy

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Synthesis, Characterisation and In Vitro Anticancer Activity of Hexanuclear Thiolato‐Bridged Arene Ruthenium Metalla‐Prisms

Author(s) -

Furrer Mona A.,

Garci Amine,

DenoyelleDiMuro Emmanuel,

Trouillas Patrick,

Giannini Federico,

Furrer Julien,

Clavel Catherine M.,

Dyson Paul J.,

SüssFink Georg,

Therrien Bruno

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201203712

Subject(s) - ruthenium , trifluoromethanesulfonate , chemistry , in vitro , tris , cisplatin , cytotoxic t cell , stereochemistry , medicinal chemistry , biochemistry , medicine , chemotherapy , catalysis

Hexanuclear thiolato‐bridged arene ruthenium metalla‐prisms of the general formula [( p ‐cymene) 6 Ru 6 (SR) 6 (tpt) 2 ] 6+ (R=CH 2 Ph, CH 2 C 6 H 4 ‐ p ‐ t Bu, CH 2 CH 2 Ph; tpt=2,4,6‐tris(4‐pyridyl)‐1,3,5‐triazine), obtained from the dinuclear precursors [( p ‐cymene) 2 Ru 2 (SR) 2 Cl 2 ], AgCF 3 SO 3 and tpt, have been isolated and fully characterised as triflate salts. The metalla‐prisms are highly cytotoxic against human ovarian cancer cells, especially towards the cisplatin‐resistant cell line A2780cisR (IC 50 <0.25 μ M ).

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