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Bis(phosphite) Ligands with Distal Regulation: Application in Rhodium‐mediated Asymmetric Hydroformylations
Author(s) -
Mon Ignasi,
Jose D. Amilan,
VidalFerran Anton
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203677
Subject(s) - rhodium , hydroformylation , vinyl acetate , chemistry , combinatorial chemistry , enantioselective synthesis , organic chemistry , catalysis , polymer chemistry , stereochemistry , copolymer , polymer
Small amounts of achiral polyether binders are employed to enhance the enantioselectivity of the hydroformylation of an array of diversely substituted substrates (increase of up to 62 % ee for vinyl acetate) mediated by chiral rhodium complexes derived from the α,ω‐bis(phosphite)–polyether ligands 1 . To the best of our knowledge, this study represents an unprecedented successful example of the positive regulation of enantioselectivity in hydroformylations.