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Palladium‐Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to Heterocyclic Acceptors
Author(s) -
Holder Jeffrey C.,
Marziale Alexander N.,
Gatti Michele,
Mao Bin,
Stoltz Brian M.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203643
Subject(s) - conjugate , chemistry , catalysis , palladium , nucleophile , flavanone , solvent , combinatorial chemistry , organic chemistry , mathematics , mathematical analysis , flavonoid , antioxidant
Flava Flavanone : Asymmetric conjugate additions to chromones and 4‐quinolones are reported utilizing a single catalyst system formed in situ from Pd(OCOCF 3 ) 2 and ( S )‐ t BuPyOX. Notably, these reactions are performed in wet solvent under ambient atmosphere, and employ readily available arylboronic acids as the nucleophile, thus providing ready access to these asymmetric heterocycles (see scheme).