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Highly Enantioselective Intermolecular Hydroamination of Allylic Amines with Chiral Aldehydes as Tethering Catalysts
Author(s) -
MacDonald Melissa J.,
Hesp Colin R.,
Schipper Derek J.,
Pesant Marc,
Beauchemin André M.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203462
Subject(s) - enantioselective synthesis , hydroamination , intermolecular force , chemistry , catalysis , allylic rearrangement , combinatorial chemistry , computer science , organic chemistry , molecule
Chirally LinkedIn : Chiral aldehydes are effective tethering catalysts for enantioselective intermolecular hydroamination, which provides access to vicinal diamine motifs in good yields and excellent enantioselectivities (see scheme). This work highlights simple chiral α‐oxygenated aldehydes as effective organocatalysts capable of efficiently inducing asymmetry through transient intramolecularity.